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PTSE® 12/36 – pharma extruder for APIs and more

Intended use

The Pharma Twin Screw Extruder PTSE® 12/36 is used for early development and preparation of samples for clinical studies. As only small batch sizes are needed for the tests, the pharma extruder is well suited for expensive active pharmaceutical substances (APIs). 

 

  • Small batch size
  • Easy cleaning and handling
  • Removable liners
  • Fast and accurate temperature regulation
  • Multiple feeding openings (top and side)
  • Modular system

 

Fast and continuous extrusion process for the pharmaceutical industry

Using the GMP qualifiable scale-up extruder you will profit from small batch sizes. You will waste less material and thus save money, particularly when running a test with ex-pensive materials such as APIs. 
Moreover, you can reach and clean all components which have contact with the used material easily having a clam shell barrel, removable liners, segmented screws and surfaces made of smooth steel. All material certificates of these components are rec-orded in a list. 

Pharma Twin Screw Extruder 12/36

Quantity
  • Applications

    • Additives
    • Starch
    • Inorganic minerals
    • Pharmaceutical mixtures
    • Plasticizer

     

    Application areas

    • Solubility enhancement of poorly soluble APIs
    • Taste masking of poorly tasting APIs
    • Rapid method for production of films
    • Modify drug release properties – reduced risk of dose dumping
    • Wet extrusion
    • Wet granulation 

     

    Peripheral equipment

    • Conveyor belt (GMP qualifiable)
    • Granulator (GMP qualifiable)
    • Gravimetric und volumetric feeding systems (GMP qualifiable)
    • Liquid feeding systems (GMP qualifiable)
    • Containment systems (GEA) e.g. Buck® System, Hicoflex® – Charge Bag

     

    Software

    Easy process control and data recording with the WinExt® Software including 

    • Feeding rate
    • Temperature of the feeding zone
    • Temperature of the heating zones and of the die head
    • Screw speed
    • Product temperature
    • Pressure
    • Torque
    • Speed of the conveyor belt
    • Granulator speed
  • Diameter 12 mm
    Process length 36 D
    Max. temperatur 200º C (optional 300 °C)
    Max. pressure 150 bar
    Max. torque 15 Nm/screw
    speed 1- 600 rpm
    dimensions (L x W x H) 1340 mm x 700 mm x 1170 mm
    Temperature Control
    • Heating
    • Cooling
    6 Controlled extruder zones
    • Electrical
    • Integrated controlled water cooling
    Downstream Feeding
    • Upper
    • Side
    Liquid, powder or micro pellets (max. 1,5 mm)
    • 0D, 10D and 27D
    • 12D
    Segmented Screw Elements Conveying & kneading elements
    Throughput 0,08 to 1 kg/h
    System Control CAN- open bus technology
    Drive Motor 3.2 kW Inverter drive
    Mains Power 3 x 400 V + N + PE, 50/60 Hz, 32A
    Weight 350 kg
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